Acetyicholine is the neurotransmitter in both sympathetic and parasympathetic ganglia. Transmission through autonomic Ganglionic is complex. Both types of cholinergic receptors are present at postganglionic neurone cell bodies. Acetylcholine, released from preganglionic fibres, produces a series of changes as follows: The primary event is that acetyicholine acts on postsynaptic nicotinic… Continue Reading Ganglionic Blockers

Adrenoceptor blocking agents or adrenoceptor antagonists are drugs that inhibit responses mediated by Adrenoceptor activation caused by epinephrine and related drugs. They also block (less completely) effects of adrenergic nerve stimulation. On the other hand, adrenergic neurone blocking drugs act on adrenergic neuronal membrane or contents and block (more completely)… Continue Reading Adrenoceptor

Drugs which produce effects similar to those of adrenergic nerve stimulation or injection of epinephrine are known as sympathomimetics or Adrenergic Agonists. Before considering Adrenergic Agonists drugs, an account of the physiology of adrenergic nerves would be helpful. Biosynthesis of Adrenergic Agonists: The varicosities (terminal swollen areas) of the adrenergic… Continue Reading Adrenergic Agonists

Anticholinergic Drugs selectively reduce or abolish the muscarinic receptor mediated effects of acetyicholine and parasympathetic stimulation. So Anticholinergic Drugs are also called antimuscarinic or parasympatholytic agents. Anticholinergic Drugs drugs inhibit the actions of endogenous acetylcholine and muscarinic agonists at muscarinic receptor sites in peripheral tissues and in the central nervous… Continue Reading Anticholinergic Drugs

Autonomous nervous system (ANS) is divided into sympathetic (adrenergic) and parasympathetic (cholinergic) divisions. Autonomous nervous system maintains homeostasis by integrating with sensory, somatomotor, endocrinal, metabolic, immunological and emotional activities. The limbic system and hypothalamus coordinate autonomic reactions with emotions. Anteromedial and posterolateral nuclei of hypothalamus are associated with cholinergic and… Continue Reading Autonomous nervous system

Tricyclic Antidepressant effect of these drugs depends on their effect on biogenic amine neurotransmitters: 1. Imipramine, clomipramine, amitriptyline and doxepin are Tricyclic Antidepressant. They block the amines norepinephrine (NE) or serotonin reuptake pumps and permit a longer sojourn of neurotransmitter at the receptor site. They also bind to c— adrenergic,… Continue Reading Tricyclic antidepressant