Once a drug has entered the bloodstream after absorption, the distribution of drug to various fluid compartments such as: a. Plasma. b. Interstitial fluid compartment (extracellular fluid space). c. Transcellular fluid compartment, e.g. fluid in the gastrointestinal tract, bronchi, CSF. d. Cellular fluid compartment (intracellular fluid compartment). Every drug is… Continue Reading Distribution of drug

Drug clearance or Kinetics of Elimination Time course of drug clearance that is absorption, distribution and elimination can be determined in mathematical terms. Such a determination is important and its clinical significance is: In understanding and planning drug regimes. In deciding drug dose schedules. In helping and supplementing to clinical… Continue Reading Drug clearance or elimination kinetics