Sjogrens syndrome is an autoimmune disorder characterized by triad of dry eyes (keratoconjunctivitis sicca), dry month (xerostomia) and arthritis. It has been classified into primary where the disease occurs by itself and secondary when it is associated with other autoimmune disorders like systemic lupus erythematosis, polymyositis, scleroderma and Rheumatid arthritis… Continue Reading Sjogrens syndrome

Goodpasture‘s syndrome constitutes triad of glomerulonephritis, Pulmonaty hemorrhage and antibody to basement membrane antigens. Its etiology is unknown. It affects people at any age. Patient generally presents with cough, breathing difficulty and haemoptysis. Anti-GBH antibodies react with an antigen in the glomerular basement membrane producing necrotizing glomerulonephritis. Rapidly progressive renal failure… Continue Reading Goodpasture‘s syndrome

Systemic lupus erythematosis is one of the important autoimmune disorders which involve various systems in the body including kidneys. Its exact etiology is not known but genetic factors and abnormal immune responses have a role to play. Circulating immune complexes composed of a variety of endogenous antigens along with auto antibodies.… Continue Reading Systemic lupus erythematosis

Myasthenia gravis is an acquired auto immune disorder of the myoneural junction resulting from attack of antibodies to acetylcholine receptors. The antibodies originate in thymus, reaching skeletal neuro muscular junctions via blood stream. The antibodies cause complement mediated damage at the neuro muscular junction producing functional blockage at the antibody… Continue Reading Autoimmune myasthenia gravis

Auto Immune Hemolytic Anemia are acquired disorders where auto-antibodies develop against one’s own red blood cells and haemolysis results from their increased destruction. Auto immune haemolytic anemia are divided into warm or cold types depending which temperature the antibody binds itself to the red cell. Warm auto immune anemia occurs at… Continue Reading Immune Hemolytic Anemia

Autoimmune hepatitis is liver inflammation that occurs when your body’s immune system turns against liver cells. The exact cause of autoimmune hepatitis is unclear, but genetic and environmental factors appear to interact over time in triggering the disease. Hepatitis which generally involves young women who are well nourished with moon… Continue Reading Autoimmune Hepatitis: Types and Treatment

Hashimoto’s thyroiditis is a chronic autoimmune mediated inflammatory disease of the thyroid which generally involves females in the age group of 40- 50 years. There is diffuse enlargement of the gland which may be firm and sometimes rubbery to hard in consistency. Sometimes the gland enlarges asymmetrically with the pyramidal lobe… Continue Reading Hashimoto’s thyroiditis (lymphadenoid or autoimmune thyroiditis)

Autoimmune disorders – An agent capable of stimulating immune response is known as antigen. It may be a protein, polysaccharide or a complex lipid. There are two kinds of immune responses. Humoral immune response involved in the production of antibodies and cellular immunity in which incompetent cells react directly against… Continue Reading Autoimmune disorders or diseases

Polymyositis and dermatomyositis are uncommon systemic rheumatic disorders characterized by inflammatory and degenerative changes in the muscles (polymyositis) or in the skin and muscles (dermatomyositis). Polymyositis is a disease of muscle featuring inflammation of the muscle fibers. The cause of the disease is not known. It begins when white blood… Continue Reading What is Polymyositis and Dermatomyositis

Polyarteritis nodosa (PAN) is a rare disease that results from blood vessel inflammation (“vasculitis”) causing injury to organ systems. The areas most commonly affected by PAN include the nerves, intestinal tract, heart, and joints. PAN can also affect the blood vessels to the kidney resulting in high blood pressure and… Continue Reading Polyarteritis Nodosa: Diagnosis and Treatment