It is an uncommon neurological disorder and is associated with pernicious anemia. There is degeneration of posterior and lateral columns of the spinal cord and of peripheral nerves leading to paraesthesia, tingling and numbness in the limbs with sensory loss, impairment of deep sensibility, motor weakness and ataxia. Aetopathogenesis Vitamin… Continue Reading Subacute combined degeneration of the cord

  Involvement of nervous system in syphilis is not very common and because of introduction of Penicillin therapy its incidence has markedly declined but in recent years it incidence has again increased due to spread of HIV. Neurosyphilis occurs only in a small percentage of cases, it being not more… Continue Reading Neurosyphilis – features, diagnosis and treatment

Tabes dorsalis is less common as compared to general paralysis of insane and affects males more as compared to females in the ratio of 4: 1. Tabetic symptoms usually appear between 10 to 12 years after primary infection, but its onset in some cases may be delayed even upto 20 years.… Continue Reading Tabes dorsalis – clinical features, diagnosis and treatment

Myasthenia gravis is an autoimmune neuro muscular disorder characterized by muscular weakness and easy fatiguability. An antibody mediated autoimmunc attack directed against acetyl choline receptors (AchR) situated in the post synaptic muscle and plate membrane is responsible for the disease. Pathophysiology There is a decrease in the number of acetylcholine… Continue Reading Myasthenia Gravis – symptoms, diagnosis and treatment

Motor neurone disease is the term applied to a group of degenerative disorders characterized pathologically by involvement of motor neurones of the spinal cord, medulla and motor cortex with sparing of peripheral nerves and sensory system. Involvement of cortical neurones gives rise to predominant upper motor neurone lesion while that of… Continue Reading Motor neurone disease

Duchenne Muscular Dystrophy (DMD) It is the commonest form of muscular dystrophy which is transmitted as X-linked recessive trait, occurring mainly in boys the females acting as carriers. Its incidence ranges from 3-5 per 100,000 live births per year. Gene for DMD has been identified. Duchene gene is located on… Continue Reading Muscular Dystrophy – Duchenne, Becker, Faclo Scapulohumeral, Limb gridle, Ocular

Polymyositis comprises of a number of conditions where muscles are damaged by a variety of pathological agents ranging from virus, toxic degenerative or to an autoimmune disorder. The term polymyositis refers to involvement of muscles while in dermatomyositis, there is in addition involvement of skin. All these conditions are now identified… Continue Reading Polymyositis – symptoms, diagnosis and treatment

Chorea is a disorder of the nervous system characterized by brief, jerky, semi purposive, irregular and explosive movements of the limbs, fleeting from one limb to the other and later on involve the whole body. These movements are followed by muscular weakness and a variable degree of emotional involvement. Pathologically the… Continue Reading Chorea – symptoms, diagnosis and treatment

It is one of the commonest neurodegenerative disorder of the elderly and affects about 1% of the people above the age of 60 years and 4% people above the age of 40 years affecting both sexes equally. Parkinsons disease was described in 1817 by James Parkinson as a clinical syndrome… Continue Reading Parkinsons disease – symptoms, diagnosis and treatment