Statistics reveals that around 1.5 to 2 million Americans suffer from traumatic brain injury to hypothalamus. Most of the victims of the traumatic brain injury may suffer from chronic and significant crippling conditions.

Most of the patients also suffer from neuroendocrine disorders due to problem in the central nervous system. In case of fatal accidents, the post mortem report reveals injury to hypothalamus and anterior pituitary.

When there are endocrine complications associated with traumatic brain problem, it could delay the process of recovery and lead to endocrine complications in the patient.

Since the hypothalamus produces important neurohormones that control the functioning of the anterior pituitary gland, any injury to hypothalamus can lead to various endocrine complications. Moreover, it is a very critical part of the human body as it maintains homeostasis.

The pituitary gland is well protected by the sella turcia of the sphenoid bone; the hypothalamus is prone to the effects of traumatic brain problems. Thus when the injury involves dysautonomia, facial fractures or cranial nerve injuries it could consequently lead to cause problems to hypothalamus.

In case of an injury to hypothalamus, this could affect the production of the Growth hormone, thyrotropin, corticotrophin and gonadotropins. In various cases there is an imbalance in the production of vasopressin and oxytocin leading to various complications after a traumatic brain injury.