Shotty adenopathy affects the lymph nodes, that are associated with the spleen, tonsils and the adenoids. The adenoids are mainly concerned with the highly organized centers, containing immune cells that function as filters, preventing the harmful antigens from entering the internal organs.

Shotty adenopathy is mostly observed in children who are affected by benign self limiting diseases that are associated with viral infections. When a child is affected by Shotty adenopathy there is a considerable increase in the normal lymphocyte count, and macrophages that are produced by the body in response to various antigens.

Some of the most common types of infections that lead to Shotty adenopathy include viral infections that lead to common upper respiratory tract infections. It may also be caused due to infectious mononucleosis and CMV. The children affected by Shotty adenopathy, may be showing signs of acquired immunodeficiency syndrome.

The causative agent could also be Rubella virus, Varicella virus and measles. There is bacterial infection; like septicemia, typhoid infection and tuberculosis, Syphilis and plague may also lead to  adenopathy.

It may also be caused by protozoal infections including toxoplasmosis. In fungal infections, cocccidiodomycosis may also lead to adenopathy in children. Several autoimmune disorders may also lead to signs and symptoms associated with lymphadenopathy in children.