Vitamin E deficiency

Vitamin E deficiency - Vitamin E is a group of natural fat-soluble compounds – ct-tocoferols.

Physiology

Vitamin E is an important anti-oxidant (free-radical scavenger) as well as involved in nucleic acid metabolism and stabilization of cellular membranes. It is widely distributed in vegetable oils,fats and nuts, specially those rich in polyunsaturated fatty acids.

RDA: 3-7 mg of cs-tocoferol equivalent/day (1 mg = 1.5 IU); higher in preterms.

Etiology

Vitamin E Deficiency is mainly seen in — a) preterms due to poor stores, b) chronic liver disease, c) Malabsorption syndrome, and d) high iron states e.g. in hemolytic anemia.

Clinically Vitamin B deficiency has been implicated in — a) 1-lemolytic anemia in preterms (at 6-10 weeks)

b) Edema in kwashiorkor

c) Degenerative neuropathy in biliary atresia or chronic liver disease, presenting as ataxia, peripheral neuropathy and posterior-column abnormalities

d) Retinopathy of prematurity

Vitamin E deficiency

Treatment of Vitamin E deficiency

Though exact role and dose of vitamin B is not established, daily oral supplementation of 5-25 IU in high-risk children e.g. preterms or those with chronic liver disease may prevent/reverse clinical abnormalities.