Diphtheritic neuropathy is the commonest complication of diphtheria and generally occurs during childhood. Diphtheria toxin is neurotoxic and results in segmental demyelination. Earliest symptom is paralysis of soft palate which occurs within a few days of the illness. It leads to hasal character of voice and regurgitation of fluids through the… Continue Reading Diphtheritic neuropathy – diagnosis and treatment

Guillain Barre Syndrome is an immune mediated disorder characterized by acute and severe polyneuropathy. The antigen here is a basic myelin protein P2 and the nerve damage is as a result of T cell mediated injury. Antimyelin antibodies are present in higher titers in early stage of the disease. A… Continue Reading Guillain Barre Syndrome – features, diagnosis and treatment

It is an uncommon neurological disorder and is associated with pernicious anemia. There is degeneration of posterior and lateral columns of the spinal cord and of peripheral nerves leading to paraesthesia, tingling and numbness in the limbs with sensory loss, impairment of deep sensibility, motor weakness and ataxia. Aetopathogenesis Vitamin… Continue Reading Subacute combined degeneration of the cord

  Involvement of nervous system in syphilis is not very common and because of introduction of Penicillin therapy its incidence has markedly declined but in recent years it incidence has again increased due to spread of HIV. Neurosyphilis occurs only in a small percentage of cases, it being not more… Continue Reading Neurosyphilis – features, diagnosis and treatment

Tabes dorsalis is less common as compared to general paralysis of insane and affects males more as compared to females in the ratio of 4: 1. Tabetic symptoms usually appear between 10 to 12 years after primary infection, but its onset in some cases may be delayed even upto 20 years.… Continue Reading Tabes dorsalis – clinical features, diagnosis and treatment

Myasthenia gravis is an autoimmune neuro muscular disorder characterized by muscular weakness and easy fatiguability. An antibody mediated autoimmunc attack directed against acetyl choline receptors (AchR) situated in the post synaptic muscle and plate membrane is responsible for the disease. Pathophysiology There is a decrease in the number of acetylcholine… Continue Reading Myasthenia Gravis – symptoms, diagnosis and treatment