Define antipyretic

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Various medical sources define antipyretic as medicine that lowers the body temperature in order to prevent or alleviate fever. It has been found to be effective in preventing or alleviating fever.

Various types of antipyretics drugs that reduce body temperature are also used as pain relieving drugs.  Ibuprofen and paracetamol are some of the most commonly available drugs that are used as examples in order to define antipyretic drugs.

These medicines are used in order to bring down the body temperature. But they may not be effective in reducing the body temperature when an individual is not having fever.

There is much controversy regarding the usage of these drugs as fever is considered to be body’s immune response to various infections. Other sources define antipyretic drugs as herbs that are administered for cooling the system and are known as refrigerants as they reduce fever. A wide variety of antipyretic drugs are available at only health stores.

Most often specialists define it is as febrifuge when they are referring to various herbs that are administered in order to reduce body temperature. Most drugs are easily available at any pharmacy store.

In fact one does not need a doctor’s prescription n in order to obtain the antipyretics drugs. It is important to follow the dosage instruction when taking the medicines. Most people may also take drugs in order to reduce body aches and pains.

The activity associated with the administration of paracetamol is that it reduces the blocks the action of cyclooxygenase. Accordingt to recent findings , it has been stated that the antipyretic activity is highly selective for cyclooxygenase -2.

Paracetamol is having analgesic and activity that can be compared to aspirin and various other NSAIDs, it also has peripheral anti inflammatory activity.

The antipyretic activity in paracetamol is dependent on various factors like high level of peroxides that are present in the inflammatory lesions. In certain cases, involving anti inflammatory activity associated with antipyretic activity, other NSAIDs may be administered.

Further studies reveal, that paracetamols, selectivity for cyclooxygenase -2 does not significantly inhibit the production of pro clotting thromoxanes. In fact, the cyclooxygenase family of enzymes that are found to be responsible for the metabolism of arachidonic acid to prosglandin hydrogen that is an unstable molecule.

Thus various pro inflammatory compounds are produced as a result of this mechanism. It ahs been found that various classical NSAIDs showing antipyretic attributes block this step where there is production of various pro inflammatory compounds.

This is based on the fact that the cyclooxygenase enzyme is highly active only when it is appropriately oxidized under normal conditions.



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